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for those living or working with the impact of trauma
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Brain-Based Attachment Interventions 
​to Transform Troubled Lives

 ​A conference with internationally renowned authors
and psychologists, Dr Dan Hughes and Dr Jon Baylin

Friday 12th March 2021  12.00pm – 5.30pm
Zoom Webinar hosted in the UK by CairnsMoir Connections & Grant Consultancy & Training (GCT)
JON'S SLIDES
BRAIN & BIOLOGY & PARENTING
WEBINAR FLYER
  • For more information on DDP see:
  • DDP Network UK Dyadic Developmental Psychotherapy (DDP) is a treatment for families with adopted or fostered children who had experienced neglect and abuse in their birth families and suffered from significant developmental trauma. 
  • The Power of DDP - Presentations from the International DDP Conference 2016
  • IRISS.FM [The Institute for Research and Innovation in Social Services (Iriss)] presents lectures, discussions and debate on current topics of interest in the social services.
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Dr Jonathan Baylin PhD, received his doctorate in Clinical Psychology from Vanderbilt University (US). While continuing his clinical practice, he has immersed himself in the study of neurobiology and in teaching mental health practitioners about the brain. He has given numerous keynotes and workshops for mental health professionals on ‘Putting the Brain in Therapy’ both internationally and regionally within the USA.

Several years ago, Dr. Baylin began a collaborative relationship
with Dr Daniel Hughes, a leader in the field of attachment-focused therapy.  Together they have authored “The Neurobiology of Attachment-Focused Therapy: Enhancing Connection and Trust in the Treatment of Children and Adolescents” and “Brain-Based Parenting: The Neuroscience of Caregiving for Healthy Attachment”.

​He is also the co-author of “Working with Traumatic Memories to Heal Adults with Unresolved Childhood Trauma” with Petra Winnette.
Dr Daniel Hughes PhD, received his doctorate in Clinical Psychology from Ohio University. For most of his professional life, he has been a clinician specializing in the treatment of children who manifest serious deficits in their emotional, cognitive, and behavioural development, and at the same time demonstrate considerable difficulty establishing and maintaining secure attachment relationships. Working primarily with foster and adopted children, he developed an attachment-focused treatment that he called Dyadic Developmental Psychotherapy (DDP). 
He is the author of many books including “Building the Bonds of Attachment”, “Principles of Attachment-Focused Parenting”, and co-author including “Creating Loving Attachments: Parenting with PACE to Nurture Confidence and Security in the Troubled Child“ with Kim Golding, “Healing Relational Trauma with Attachment-Focused Interventions: DDP With Children and Families” with Kim Golding and Julie Hudson, and “Settling Troubled Pupils to Learn – why relationships matter in school” with Louise Bomber. His latest publication is “The Little Book of Attachment: Theory to Practice in Child Mental Health“ with Ben Gurney-Smith.
Further references:

Dynorphin references from Jon Baylin presentation

Cleck JN, Blendy JA. Making a bad thing worse: adverse effects of stress on drug addiction. J Clin Invest 2008;118:454–461. [PubMed: 18246196]
de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease.

Nat Rev Neurosci 2005;6:463–475. [PubMed: 15891777]
Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology 2009a;56(Suppl 1):18–31. [PubMed: 18725236]
Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid
system. J Neurosci 2008;28:407–414. [PubMed: 18184783]

Default Mode Network from Jon Baylin presentation
Hamilton JP, Farmer M, Fogelman P, Gotlib IH. Depressive rumination, the default-mode network, and the dark matter of clinical science. Biological Psychiatry. 2015; 78:224–230. [PubMed: 25861700]
Harrison BJ, Pujol J, Ortiz H, Fornito A, Pantelis C, Yücel M. Modulation of brain resting-state networks by sad mood induction. PLoS ONE. 2008; 3:e1794. [PubMed: 18350136]
Kaiser RH, Andrews-Hanna JR, Wager TD, Pizzagalli DA. Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA Psychiatry. 2015; 72:603–611. [PubMed: 25785575]
Kelly AMC, Di Martino A, Uddin LQ, Shehzad Z, Gee DG, Reiss PT, Margulies DS, Castellanos FX, Milham MP. Development of anterior cingulate functional connectivity from late childhood to early adulthood. Cerebral Cortex. 2009; 19:640–657. [PubMed: 18653667]
Majer M, Nater UM, Lin JM, Capuron L, Reeves WC. Association of childhood trauma with cognitive function in healthy adults: a pilot study. BMC Neurology. 2010; 10:61. [PubMed: 20630071]
Margulies DS, Kelly AMC, Uddin LQ, Biswal BB, Castellanos FX, Milham MP. Mapping the functional connectivity of anterior cingulate cortex. NeuroImage. 2007; 37:579–588. [PubMed: 17604651] 
Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry. 1999; 156:675–682. [PubMed:
10327898]
McCabe C, Mishor Z. Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers. NeuroImage. 2011; 57:1317–1323. [PubMed: 21640839]
Menon V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends in Cognitive Sciences. 2011; 15:483–506. [PubMed: 21908230]
Menon V, Uddin LQ. Saliency, switching, attention and control: a network model of insula function. Brain Structure and Function. 2010; 214:655–667. [PubMed: 20512370]
Pannekoek JN, Veer IM, van Tol MJ, van der Werff SJA, Demenescu LR, Aleman A, Veltman DJ, Zitman FG, Rombouts SARB, van der Wee NJA. Aberrant limbic and salience network restingstate functional connectivity in panic disorder without comorbidity. Journal of Affective Disorders. 2013; 145:29–35.
[PubMed: 22858265]
Perlman SB, Almeida JRC, Kronhaus DM, Versace A, LaBarbara EJ, Klein CR, Phillips ML. Amygdala activity and prefrontal cortex-amygdala effective connectivity to emerging emotional faces distinguish remitted and depressed mood states in bipolar disorder. Bipolar Disorders. 2012; 14:162–174. [PubMed:
22420592]
Pizzagalli D. Frontocingulate dysfunction in depression: toward biomarkers of treatment response. Neuropsychopharmacology. 2011; 36:183–206. [PubMed: 20861828]
Price JL, Drevets WC. Neurocircuitry of mood disorders. Neuropsychopharmacology. 2010; 35:192– 216. [PubMed: 19693001]
Rogosch FA, Cicchetti D, Aber JL. The role of child maltreatment in early deviations in cognitive and affective processing abilities and later peer relationship problems. Development and Psychopathology. 1995; 7:591–609.
Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD. Dissociable intrinsic connectivity networks for salience processing and executive control. Journal of Neuroscience. 2007; 27:2349–2356. [PubMed: 17329432]
Sheline YI, Barch DM, Price JL, Rundle MM, Vaishnavi SN, Snyder AZ, Mintun MA, Wang S, Coalson RS, Raichle ME. The default mode network and self-referential processes in depression. Proceedings of the National Academy of Sciences USA. 2009; 106:1942–1947.
Spann MN, Mayes LC, Kalmar JH, Guiney J, Womer FY, Pittman B, Mazure CM, Sinha R, Blumberg HP. 
Childhood abuse and neglect and cognitive flexibility in adolescents. Child Neuropsychology. 2012; 18:182–189. [PubMed: 21942637]
Sundermann B, Beverborg MOL, Pfieiderer B. Toward literature-based feature selection for diagnostic classification: a meta-analysis of resting-state fMRI in depression. Frontiers in Human Neuroscience. 2014; 8:692. [PubMed: 25309382]
Versace A, Ladouceur CD, Romero S, Birmaher B, Axelson DA, Kupfer DJ, Phillips ML. Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging study. Journal of the American Academy of Child and Adolescent Psychiatry. 2010;
49:1249–1259. [PubMed: 21093774]
Weisenbach SL, Kassel MT, Rao J, Weldon AL, Avery ET, Briceño EM, Ajilore O, Mann M, Kales HC, Welsh RC, Zubieta J-K, Langenecker SA. Differential prefrontal and subcortical circuitry engagement during encoding of semantically related words in patients with late-life depression. International Journal of
Geriatric Psychiatry. 2014; 29:1104–1115. [PubMed: 24948034]
Whitfield-Gabrieli S, Ford JM. Default mode network activity and connectivity in psychopathology. Annual Review of Clinical Psychology. 2012; 8:49–76

Habenula references from Jon Baylin presentation
Sartorius A, Kiening KL, Kirsch P, von Gall CC, Haberkorn U, Unterberg AW, Henn FA, Meyer- Lindenberg A. Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient. Biol Psychiatry. 2010 Jan 15;67(2):e9-e11. doi:10.1016/j.biopsych.2009.08.027.
Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008 Jan;33(2):368-77. Epub 2007 Apr 11.
Ely BA, Xu J, Goodman WK, Lapidus KA, Gabbay V, Stern ER. Resting-state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depression. Hum Brain Mapp. 2016 Jul;37(7):2369-84. doi: 10.1002/hbm.23179. Epub 2016 Mar 16.
Ramasubbu R, Anderson S, Haffenden A, Chavda S, Kiss ZH. Double-blind optimization of subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study. J Psychiatry Neurosci. 2013 Sep;38(5):325-32. doi: 10.1503/jpn.120160.
Riva-Posse P, Choi KS, Holtzheimer PE, McIntyre CC, Gross RE, Chaturvedi A, Crowell AL, Garlow SJ, Rajendra JK, Mayberg HS. Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression. Biol Psychiatry.
2014 Dec 15;76(12):963-9. doi: 10.1016/j.biopsych.2014.03.029. Epub 2014 Apr 13.
christoph, G. R., Leonzio, R. J. & Wilcox, K. S. Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and
ventral tegmental area of the rat. J. Neurosci. 6, 613–619 (1986).
Ji, H. & Shepard, P. D. Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. J.
Neurosci. 27, 6923–6930 (2007).
Matsumoto, M. & Hikosaka, O. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447, 1111–1115 (2007)
Geisler, S. & Trimble, M. The lateral habenula: No longer neglected. CNS Spectr. 13, 484–489 (2008
Sartorius, A. et al. Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient. Biol.
Psychiatry 67, 9–11 (2010).
Li, B. et al. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 470, 535–539 (2011)
Shabel, S. J., Proulx, C. D., Piriz, J. & Manilow, R. Mood regulation.
GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment. Science. 345, 1494–1498 (2014).
Tchenio, A., Lecca, S., Valentinova, K. & Mameli, M. Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like
symptoms. Nat. Commun. 8, 1135, https://doi.org/10.1038/s41467-017- 01192-1 (2017).
Yang, Y. et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature 554, 317–322 (2018)
Winter, C., Vollmayr, B., Djodari-Irani, A., Klein, J. & Sartorius, A. Pharmacological inhibition of the lateral habenula improves depressive-like
behavior in an animal model of treatment resistant depression. Behav Brain Res 216, 463–465 (2011)
Huang, L. et al. A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy. Neuron 102, 128–142 (2019).
Meye, F. J. et al. Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse. Nat. Neurosci. 19,
1019–1024 (2016).
Lazaridis, I. et al. A hypothalamus-habenula circuit controls aversion. Mol. Psychiatry 24, 1351–1368 (2019).
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B. & Holland, P. C. The Rostromedial Tegmental Nucleus (RMTg), a major GABAergic afferent to
midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron 61, 786–800 (2009).

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